The mission of the SJS/TEN research program at VUMC is to 1) improve preventive efforts and facilitate translation of genetic screening into the clinical and pre-clinical setting to prevent SJS/TEN through excluding patients at risk from high risk drugs and facilitating the development of safer drugs less likely to cause SJS/TEN. 2) Identify biomarkers associated with SJS/TEN that could lead to earlier diagnosis and specific and sensitive measures for point of care diagnosis in communities without access to specialty care (to expedite transition into specialty care such as Burns centers 3) Identify the mechanisms driving SJS/TEN that will lead to an understanding of the molecular and cellular signals that will lead to discovery of targeted therapies to prevent morbidity and mortality associated with SJS/TEN.